Facilities

Center for Integrated Approaches to Complex Diseases (CIACD)

University of Michigan, School of Public Health SPH I
1415 Washington Heights, Room 1855
Ann Arbor, MI 48109-2029
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Fax: (734) 764-6250
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This is the primary location for the CIACD, which is located on the medical center campus of the University of Michigan. The Center occupies a 4,400 square foot area that houses research investigators as well as the offices of more than 20 staff including biostatisticians, epidemiologists, data managers, program coordinators and technical staff. Currently, the Center acts as the location for administration and implementation of the Michigan Bone Health & Metabolism Study, SWAN II Core Protocol, SWAN Repository, the SWAN Functional Limitations Study, the SWAN Sleep Study, and the Estrogen Metabolism Study.

Study of Women’s Health Across the Nation (SWAN) Clinical Site

University of Michigan, School of Public Health SPH I
1415 Washington Heights, Room #B855
Ann Arbor, MI 48109-2029
Phone: (734) 647-5068
Fax: (734) 764-6250
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Located in the 3,200 square feet SWAN Field Center are three full-time staff members. The facility has amenities for bone densitometry, performance-based physical functioning assessment, four private interviewer stations that double as staff offices, a phlebotomy and biological specimen processing laboratory, physical assessment space, and a small administrative office.

CLASS Laboratory Site

1900 Green Road
Ann Arbor, MI 48109-2029
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The CLASS laboratory is a 1,700 sq. ft. facility remote from the main University campus that contains equipment to run assays on ACS:180 automated immunoassay analyzers (currently five); log raw data from the analyzers; analyze the data offline; assess validity of assay results; re-freeze samples rapidly; return samples to their established locations; transfer encrypted data over ethernet and fiberoptic links; store data in a central SQL database; format results into a form for electronic transfer; and transfer data by any of several means including PGP encrypted e-mail attachments and FTP servers. The chemiluminescence-based ACS:180 analyzers are equipped with extended operations modules to manage water supply and waste fluid, and manufacturing software to permit independent assay development. It also includes an HPLC system and resources to do column chromatography. The CLASS Laboratory contains a Hamilton AT pipetting station capable of pipetting samples and reagents from tubes to ELISA microtiter plates a Molecular Devices Spectramax and the associated SoftMAX Pro data reduction software. These enable semi-automation of an entire ELISA protocol.

The CIACD currently houses (14) ultralow Revco and Scientemp freezers at the CLASS labs in a temperature and humidity controlled environment with extensive automated and human monitoring for temperature and power stability. Samples are barcoded and stored in specified freezer location (box, rack, freezer) and an electronic inventory is maintained to characterize the barcoded sample, its location and characteristics of the sample including volume, state of sample (i.e., hemolyzed), and relevant participant characteristics (i.e., fasted).

Collaborating Laboratories

Michigan Diabetes Research and Training Center (MDRTC) Chemistry Laboratory

400 North Ingalls, Room G148
Ann Arbor, MI 48109
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The Chemistry Laboratory of the Michigan Diabetes Research and Training Center, located on the campus of The University of Michigan Medical School, provides analytical services to the diabetes research community. In excess of 20,000 analyses are performed annually from a menu of 32 tests. In addition the lab attempts to develop and offer new tests to meet the specific and changing needs of investigators. The laboratory gives the unique assurance of continuity of assay protocols and reagents for longitudinal studies, assuring methodological consistency for the duration of the study. Analytical methods include general blood chemistry, chemiluminescence, immunoassay, radioimmunoassay and ELISA. Testing is performed on state-of-the art equipment including a TC Matrix Chemistry System, Cobas Mira Plus random access analyzer, Immulite Automated Immunoassay System, Wizard 1470 gamma counter, and ELx808 IU Microplate Reader.

Mancuso Lab - Pulmonary Immunology and adipokine biology

University of Michigan Health System
1415 Washington Heights, Room 6627
Ann Arbor, MI 48109
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Dr. Mancuso of the Environmental Health Sciences   department at the School of Public Health occupies 550 square feet of laboratory space in which he conducts assay sampling among other activities. This lab is equipped with necessary facilities for animal surgery, cell isolation, and enzyme immunosorbant assays, and cell culture. In addition, Dr. Mancuso has access to a Molecular Devices Spectromaxplus plate reader in an adjacent laboratory.

Dr. Mancuso’s lab is equipped with a laminar flow biological safety hood, tissue homogenizer, CO2 incubator, inverted microscope, fluorescent and microscopes with color and high resolution camera’s for image acquisition, a fume hood, water bath, analytical balances, refrigerated centrifuge, micro-centrifuge, cytospin-slide centrifuge, a 4°C refrigerator, a -70°C freezer. Within adjacent laboratories in the Department of Environmental Health Sciences are additional support equipment including a UV spectrophotometer, liquid nitrogen storage tanks, standard and fluorescent 96-well plate readers, and fluorescent and con-focal microscopes. Dr. Mancuso also has access to thermal cyclers for RT-PCR, one ultracentrifuge, two electrophoresis units, one scintillation counter, and a Fuji Scanner for densitometric analysis of gels.